Thermo Fisher Scientific Phospho-NPM1 (Ser125) Polyclonal Antibody
인산화된 NPM1(Ser125)을 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 생쥐, 랫트 반응성. 고순도 액상 형태로 제공되며, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Nucleophosmin around the phosphorylation site of Ser125 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899248 |
Product Specific Information
This antibody detects endogenous levels of Nucleophosmin only when phosphorylated at Ser125.
Target Information
NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly and transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53.
It shuttles between the nucleus, cytoplasm, and nucleolus, chaperoning core histones and preventing protein aggregation.
NPM1 is associated with centrosome duplication and acts as a substrate of CDK2/cyclin E.
Due to its interaction with tumor-associated chromosome translocations, NPM1 forms fusion proteins such as NPM-ALK, NPM-RAR, and NPM-MLF1, contributing to oncogenic processes.
Dysfunction of NPM1 is linked to diseases including acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-114612_NPM1_P06748-1_Rabbit.svg, PA5-114612_NPM1_P06748-1_Rabbit_PDP.jpeg)
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