Thermo Fisher Scientific Phospho-MYPT1 (Ser473) Polyclonal Antibody
MYPT1 단백질의 Ser473 인산화 형태를 선택적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 고순도 액상 형태, PBS/50% glycerol buffer에 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MYPT1 around the phosphorylation site of Ser473 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899245 |
Product Specific Information
This antibody detects endogenous levels of MYPT1 only when phosphorylated at Ser473.
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase.
Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho.
Activated RhoA interacts with the myosin-binding subunit (MBS) of myosin phosphatase and regulates phosphorylation of the myosin light chain (MLC).
Rho-associated kinase (Rho-kinase), activated by GTP-bound RhoA, phosphorylates MBS and inactivates myosin phosphatase.
Overexpression of RhoA or activated RhoA increases phosphorylation of MBS and MLC, indicating that Rho inhibits myosin phosphatase via Rho-kinase.
Several transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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