Thermo Fisher Scientific HLA-BC Monoclonal Antibody (B1.23.2), PE, eBioscience
인간 HLA-B 및 HLA-C 항원을 인식하는 B1.23.2 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. PE 형광체 결합으로 565/576 nm에서 우수한 신호를 제공합니다. 고순도 친화 크로마토그래피 정제, 4°C 암소 보관 권장.
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Thermo Fisher Scientific HLA-BC Monoclonal Antibody (B1.23.2), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B1.23.2 |
| Conjugate | PE |
| Excitation/Emission Max | 565/576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10732346 |
Additional Formats
Product Specific Information
This B1.23.2 monoclonal antibody recognizes human Leukocyte Antigens (HLA) B and C, which correspond to MHC Class I in humans.
HLA-B and HLA-C are expressed on nearly all cell types and form heterodimers with beta-2 microglobulin at the cell surface.
These complexes are essential for presenting endoplasmic reticulum-derived peptides to immune cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells.
Recommended use: 5 µL (0.25 µg) per test in a final volume of 100 µL (10⁵–10⁸ cells/test).
Excitation/Emission: 488–561 nm; Emission 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
HLA-class I antigens are widely distributed on human nucleated cells.
Expression levels of HLA-ABC may vary in pathological states — malignant cells may lose HLA-ABC, while hepatocytes in alcoholic hepatitis, biliary cirrhosis, and chronic active hepatitis may show enhanced expression.
HLA and MHC antibodies are key tools in Immunopeptidomics, enabling identification and characterization of neoantigens using LC-MS/MS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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