Thermo Fisher Scientific SLITRK1 Polyclonal Antibody
SLITRK1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제되었으며, 신경 발달 및 신경돌기 성장 연구에 적합.
- 카탈로그번호
- PA523064
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,500 |
| Immunohistochemistry (IHC) | 1:250 |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal region of the human Slitrk1 protein (within residues 250–400). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152402 |
Product Specific Information
The target sequence has 84% sequence homology with rat.
Target Information
SLIT and NTRK-like family 1 (Slitrk1) is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1–6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains.
Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth.
While Slitrk1 variants have been suggested to be associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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