Thermo Fisher Scientific JMJD2C Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

-

Immunocytochemistry (ICC/IF)

1:100

-

Immunoprecipitation (IP)

Assay-Dependent

-

ChIP assay (ChIP)

Assay-Dependent

-

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to an internal region of the human JMJD2C protein (within residues 450-600). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:JMJD2C,uniProtId:Q9H3R0-1,ncbiNodeId:9606,antigenRange:450-600,antigenLength:1056,antigenImageFileName:PA5-23065_JMJD2C_Q9H3R0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-23065_JMJD2C_Q9H3R0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152049

Product Specific Information

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Target Information

Jumonji domain-containing protein 2C (JMJD2C)/ Lysine-specific demethylase 4C (KDM4C) is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3; thereby, playing a central role in histone code. KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It demethylates trimethylated H3 Lys-9 and H3 Lys-36 residues. There is no activity on mono- or dimethylated residues. Demethylation of Lys residues generates formaldehyde and succinate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.