Thermo Fisher Scientific JMJD2C Polyclonal Antibody
JMJD2C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, IP, ChIP 등 다양한 응용 가능. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제된 액상 시약으로 안정적인 결과 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:10,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| ChIP assay (ChIP) | Assay-Dependent | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal region of the human JMJD2C protein (within residues 450–600). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152049 |
Product Specific Information
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Target Information
Jumonji domain-containing protein 2C (JMJD2C), also known as Lysine-specific demethylase 4C (KDM4C), is a histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, playing a central role in histone code regulation.
KDM4C does not demethylate histone H3 Lys-4, H3 Lys-27, or H4 Lys-20. It acts on trimethylated H3 Lys-9 and H3 Lys-36 residues, with no activity on mono- or dimethylated forms.
Demethylation of Lys residues generates formaldehyde and succinate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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