Thermo Fisher Scientific CD8A (Cytotoxic/Suppressor T-Cell Marker) Monoclonal Antibody (T8/209)
CD8A 단백질을 표적하는 T8/209 클론의 Mouse Monoclonal Antibody로, 인간 및 비인간 영장류 반응성을 지님. ELISA 등 연구용으로 사용되며, Protein A/G 정제 및 PBS 버퍼 내 200 µg/mL 농도로 제공. 세포 분화 및 CTL 활성화 연구에 적합.
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Applications
- ELISA (ELISA)
Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T8/209 |
| Immunogen | Recombinant human T8 (CD8a) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, playing an integral role in signal transduction, T cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
CD8α is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Upon ligation with MHC-I/peptide complexes on antigen-presenting cells (APCs), CD8 recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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