Thermo Fisher Scientific HAP 1 Polyclonal Antibody
Thermo Fisher Scientific의 HAP1 폴리클로날 항체는 인간 HAP1 단백질을 인식하며 Western blot 및 IHC에 적합합니다. Rabbit Ig 폴리클로날 타입으로, 동결건조 형태이며 장기 보관 시 -20°C에서 안정적입니다. 신경퇴행성 질환 연구용으로 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal of human HAP1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: HAP1
Target Information
Huntington’s disease (HD) is a neurodegenerative disorder characterized by loss of striatal neurons, caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through two-hybrid library screening; its binding to huntingtin correlates with the polyglutamine tract expansion.
HAP1 interacts with cytoskeletal proteins such as dynactin and pericentriolar autoantigen protein 1, suggesting a role in vesicular trafficking or organelle transport. It also participates in huntingtin-enhanced BDNF transport along cellular microtubules. Attenuation of this process leads to loss of neurotrophic support and neuronal toxicity, potentially contributing to disease pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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