Thermo Fisher Scientific p23 Polyclonal Antibody
Thermo Fisher Scientific의 p23 Polyclonal Antibody는 인간, 생쥐, 랫트 시료에서 p23 단백질을 검출하는 토끼 유래 IgG 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PTGES3 (Accession Q15185), corresponding to amino acid residues F120–E160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852121 |
Product Specific Information
Antibody detects endogenous levels of total p23.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with various proteins in both stable and transient fashion. These include heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins termed p23, p60, and p48.
p23, along with HSP70, HSP90, and p60, combines with progesterone receptor (PR) as members of a transient intermediate complex. The cloned human p23 encodes a 160-amino-acid protein highly conserved between species and shows no homology to previously identified proteins. It is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies suggest p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. Although its exact function is not fully defined, p23 appears to be an important factor in PR function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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