Thermo Fisher Scientific S100A12 Polyclonal Antibody
S100A12 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 IHC(P) 실험에 적합합니다. Human 및 Mouse 시료에 반응하며, Affinity chromatography로 정제되었습니다. 1 mg/mL 농도의 액상 제품으로, PBS(50% glycerol) 저장 용액에 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human S100A12 (Accession P80511), corresponding to amino acid residues M1–K49 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852122 |
Product Specific Information
This antibody detects endogenous levels of total S100A12.
Target Information
S100A12 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of various cell types and are involved in regulating cellular processes such as cell cycle progression and differentiation.
S100A12 participates in calcium-dependent signal transduction pathways and may regulate cytoskeletal components, influencing neutrophil activities. It also acts as a ligand for RAGE, triggering cellular activation in mononuclear phagocytes, lymphocytes, and endothelial cells. Activation of NF-κB, a key transcription factor in inflammatory responses, is mediated by S100A12/RAGE interaction. Additionally, S100A12 exhibits antimicrobial properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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