Thermo Fisher Scientific Cyclin D3 Polyclonal Antibody

Thermo Fisher Scientific Cyclin D3 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200

Species Reactivity

• Human
• Mouse
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

Synthetic peptide corresponding to amino acids 249–292 of Human Cyclin D3.

Conjugate

• Unconjugated

Form

• Liquid

Concentration

• 1 mg/mL

Purification

• Antigen affinity chromatography

Storage Buffer

• PBS, pH 7.2, with 50% glycerol

Contains

• 0.02% sodium azide

Storage Conditions

• Store at 4°C for short term
• For long term storage, store at –20°C, avoiding freeze/thaw cycles

Shipping Conditions

• Wet ice

RRID

• AB_2803015

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance during the cell cycle. Cyclins regulate CDK kinases and form complexes with CDK4 or CDK6, essential for the G1/S transition. Cyclin D3 interacts with and phosphorylates tumor suppressor protein Rb. CDK4 activity associated with Cyclin D3 is required for cell cycle progression through G2 phase into mitosis after UV radiation. Multiple transcript variants encoding different isoforms have been identified.
Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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