Thermo Fisher Scientific Kir4.1 (KCNJ10) Polyclonal Antibody
Kir4.1 (KCNJ10) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합. Human 및 Rat 시료 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific Kir4.1 (KCNJ10) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the mid-protein of Human Kir4.1 (C-QTHQTKEGENIR) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735995 |
Product Specific Information
A 1:1,000 dilution of PA5-77822 was sufficient for detection of Kir4.1 in 15 µg of rat liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 42 kDa.
Target Information
The KIR (inwardly rectifying potassium channel) family allows potassium to flow preferentially into cells.
KIR4.1 (also known as Kir1.2) is highly expressed in the brain, particularly in glial cells, astrocytes, and cortical neurons. It is also found in myelin-synthesizing oligodendrocytes and plays a crucial role in myelination during nervous system development.
The human KIR4.1 gene maps to chromosome 1.
KIR4.2 (Kir1.3) is expressed in kidney, lung, heart, thymus, and thyroid during development and maps to chromosome 21, possibly contributing to Down syndrome pathogenesis.
KIR5.1 forms functional channels only when coexpressed with KIR4.1 or KIR4.2 in kidney and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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