Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Thermo Fisher Scientific의 FANCD2 Polyclonal Antibody는 인간 FANCD2 단백질(1401–1451 영역)을 인식하는 토끼 IgG 항체로, IHC(P) 등 다양한 면역조직화학 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Monkey, Gorilla, and Crab-eating macaque
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis and is involved in the repair of DNA double-stranded breaks via homologous recombination and single-stranded annealing. FANCD2 is required for BLM targeting/stabilization to non-centromeric abnormal structures induced by replicative stress and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, affecting all bone marrow elements and causing anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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