Thermo Fisher Scientific ITCH Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal ITCH 항체. Western blot 및 ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 제품. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
ELISA
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | ITCH antibody for a 15 amino acid peptide near the amino terminus of human ITCH. The immunogen is within amino acids 40–90 of ITCH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718645 |
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy.
The protein encoded by this gene interacts with atrophin-1 and is a member of the NEDD4-like protein family.
This family of proteins are E3 ubiquitin-ligase molecules that regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain.
It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling.
It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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