Thermo Fisher Scientific SLC22A18 Polyclonal Antibody
SLC22A18 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot에 적합하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 단백질은 43 kDa 크기의 내인성 단백질을 검출합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 360–412 of human ORCTL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553420 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 43 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
ORCTL2 (Organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A, or SLC22A18, is a 424 amino acid multi-pass membrane protein localized at the apical membrane surface of renal proximal tubules.
It is highly expressed in kidney, liver, and colon, and at lower levels in heart, brain, and lung.
Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations via a proton efflux antiport mechanism and may also transport chloroquine and quinidine-related compounds in the kidney.
Defects in ORCTL2 are associated with breast and lung cancer and are a cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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