Thermo Fisher Scientific FLT1 Monoclonal Antibody (OTI11G5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FLT1 (VEGFR1) is a receptor tyrosine kinase involved in angiogenesis. It plays critical roles in both physiological and pathological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation. In adults, it can promote endothelial cell proliferation, survival, and angiogenesis in a cell-type-specific manner.
It has high affinity for VEGFA but relatively low kinase activity and may function as a negative regulator of VEGFA signaling by sequestering VEGFA and preventing its interaction with KDR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.