Thermo Fisher Scientific Cytokeratin 18 (KRT18) Recombinant Rabbit Monoclonal Antibody (KRT18/7056R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues of the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18.
Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns assist in distinguishing different epithelial malignancies and are valuable in tumor differential diagnosis, cytopathology, and flow cytometry assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 항체의 항원 구조 이미지: Cytokeratin 18, UniProt ID: P05783-1)