Thermo Fisher Scientific Phospho-TAK1 (Ser412) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence: RRSIQ

Target Information

TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to regulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, endothelin, and ephrine. TAK1 regulates expression of von Hippel-Lindau tumor suppressor, represses PDGF-B and integrins β1/β5, and contributes to wound healing. It plays a critical role in IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3 binding and polyubiquitination, leading to TAK1 autophosphorylation and subsequent phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, indicating a role in lifespan regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.