Thermo Fisher Scientific Phospho-TAK1 (Ser412) Polyclonal Antibody
Phospho-TAK1 (Ser412) 특이적 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합합니다. Mouse와 Rat 시료 반응성이 있으며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S412 of human TAK1 (NP_003179.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855545 |
Product Specific Information
Immunogen sequence: RRSIQ
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to regulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, endothelin, and ephrine. TAK1 regulates expression of von Hippel-Lindau tumor suppressor, represses PDGF-B and integrins β1/β5, and contributes to wound healing. It plays a critical role in IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3 binding and polyubiquitination, leading to TAK1 autophosphorylation and subsequent phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, indicating a role in lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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