Thermo Fisher Scientific ABCA1 Monoclonal Antibody (3A1.891.3)
ABCA1 단백질을 인식하는 쥐 반응성 Rat IgG1 단일클론 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 ABCA1에는 반응하지 않으며, Tangier 질환 관련 연구에 유용합니다. 액상 형태로 -20°C 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A1.891.3 |
| Immunogen | Synthetic peptide corresponding to the N-terminal loop residues 200–250 of mouse ABCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_779127 |
Product Specific Information
This antibody does not react with human ABCA1.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by absence of plasma HDL, cholesterol ester deposition in the reticulo-endothelial system, and altered lipid trafficking.
ABCA1 mediates apo-A1–associated export of cholesterol and phospholipids from cells. It is expressed on the plasma membrane and Golgi complex, regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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