Thermo Fisher Scientific ABCA1 Monoclonal Antibody (5A1-1422.11)

Applications

Western Blot (WB)

• Assay-dependent

Flow Cytometry (Flow)

• 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody is not reactive in Western blot or ELISA applications.

Target Information

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD).
TD is an autosomal recessive disorder characterized by:

• Absence of plasma HDL
• Cholesterol ester deposition in the reticulo-endothelial system
• Deviations in cellular lipid trafficking

ABCA1 mediates the apo-A1-associated export of cholesterol and phospholipids from the cell.
It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.