Thermo Fisher Scientific ABCA1 Monoclonal Antibody (5A1-1422.11)
ABCA1 단백질을 인식하는 쥐 반응성 Rat IgG2a 단클론 항체로, Flow Cytometry에 사용 가능. Tangier 병 관련 연구 등 콜레스테롤 수송 메커니즘 분석에 유용. 단백질 A/G 정제, 액상 형태로 제공되며 -20°C 이하 보관 권장.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5A1-1422.11 |
| Immunogen | Mouse ABCA1-expressing HeLa stable transfectants |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2220014 |
Product Specific Information
This antibody is not reactive in Western blot or ELISA applications.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD).
TD is an autosomal recessive disorder characterized by:
- Absence of plasma HDL
- Cholesterol ester deposition in the reticulo-endothelial system
- Deviations in cellular lipid trafficking
ABCA1 mediates the apo-A1-associated export of cholesterol and phospholipids from the cell.
It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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