Thermo Fisher Scientific ETS1 Polyclonal Antibody
ETS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 적합합니다. Human, Mouse, Rat에 반응하며 액상 형태로 제공됩니다. Affinity Chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 342–441 of human ETS1 (NP_005229.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.98 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806140 |
Product Specific Information
Immunogen sequence:
LELLTDKSCQ SFISWTGDGW EFKLSDPDEV ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTAGKRYV YRFVCDLQSL LGYTPEELHA MLDVKPDADE
Positive Samples: Mouse thymus
Cellular Location: Cytoplasm, Nucleus
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family.
It is a multifunctional protein with:
- N-terminal pointed domain
- Central transactivation domain
- Two auto-inhibitory domains flanking the conserved C-terminal ETS domain
ETS1 interacts with factors including PEBP2alphaA and p300/CBP to mediate transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression is upregulated in resting T-cells.
Activity is modulated by transcription factors such as AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies.
ETS1 interacts with EAP1/Daxx to repress MMP1 and BCL2 transactivation, and with STAT6 to modulate Socs-1 expression induced by IL-4.
It also interacts with GATA3 to positively regulate Tax-1 dependent IL-5 expression.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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