Thermo Fisher Scientific ETS1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
LELLTDKSCQ SFISWTGDGW EFKLSDPDEV ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTAGKRYV YRFVCDLQSL LGYTPEELHA MLDVKPDADE

Positive Samples: Mouse thymus
Cellular Location: Cytoplasm, Nucleus

Target Information

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family.
It is a multifunctional protein with:

• N-terminal pointed domain
• Central transactivation domain
• Two auto-inhibitory domains flanking the conserved C-terminal ETS domain

ETS1 interacts with factors including PEBP2alphaA and p300/CBP to mediate transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression is upregulated in resting T-cells.
Activity is modulated by transcription factors such as AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies.
ETS1 interacts with EAP1/Daxx to repress MMP1 and BCL2 transactivation, and with STAT6 to modulate Socs-1 expression induced by IL-4.
It also interacts with GATA3 to positively regulate Tax-1 dependent IL-5 expression.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.