Thermo Fisher Scientific SON Polyclonal Antibody
Human SON 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로 HBV 관련 유전자 조절 및 세포 내 스플라이싱 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SON. Recombinant protein control fragment (Product #RP-104639) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662627 |
Product Specific Information
Immunogen sequence:
TCMVSETPAMS AEPTVLASEP PVMSETAETF DSMRASGHVA SEVSTSLLVP AVTTPVLAES ILEPPAMAAP ESSAMAVLES SAVTVLESST VTVL
Highest antigen sequence identity to the following orthologs:
- Mouse: 56%
- Rat: 54%
Target Information
The SON protein binds to specific DNA sequences upstream of the core promoter and second enhancer of human hepatitis B virus (HBV). This binding represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions.
It shows sequence similarity with other DNA-binding structural proteins such as gallin, MYC family oncoproteins, and MOS.
SON may also play roles in protecting cells from apoptosis and in pre-mRNA splicing.
Several transcript variants encoding different isoforms have been described, with two full-length variants determined.
[Provided by RefSeq]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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