Thermo Fisher Scientific WNT10A Polyclonal Antibody
WNT10A 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 5 µg/mL로 검증됨. 인간, 개, 소 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 암 연구 및 WNT 신호전달 경로 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from internal region of human WNT10A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551666 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Dog, Bovine (100%)
Mouse, Rat, Hamster, Bat, Rabbit (94%)
Opossum (81%)
Target Information
The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins are involved in oncogenesis and several developmental processes, including regulation of cell fate and patterning during embryogenesis.
WNT10A is strongly expressed in cell lines of promyelocytic leukemia and Burkitt’s lymphoma, and coexpressed with WNT6 in colorectal cancer cell lines. Overexpression may play key roles in carcinogenesis through activation of the WNT–beta-catenin–TCF signaling pathway.
WNT10A and WNT6 genes are clustered in the chromosome 2q35 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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