Thermo Fisher Scientific PSF/SFPQ Polyclonal Antibody
PSF/SFPQ 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등 다양한 응용에 적합하며, 인간 SFPQ 단백질의 1-50 아미노산 영역을 면역원으로 사용. 알츠하이머병 등 신경퇴행성 질환 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Polypyrimidine tract-binding protein-associated splicing factor (SFPQ). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
SFPQ (also named PSF) encodes a nuclear factor involved in splicing and regulation of gene expression.
It likely forms a heteromer with NONO and participates in DNA pairing and DNA break repair.
SFPQ has been identified as a downstream target of tau protein; depletion and cytoplasmic accumulation have been observed in neurons and astrocytes of Alzheimer’s disease brains.
Reduced SFPQ levels may progress with tau pathology, suggesting a key role in neurodegenerative diseases including Alzheimer’s disease.
SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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