Thermo Fisher Scientific Phospho-JunD (Ser259) Polyclonal Antibody
JunD 단백질의 Ser259 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 적합하며, 인간, 생쥐, 랫트 시료에 반응합니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JUND (Accession P17535), corresponding to amino acid residues around phosphorylated Ser259 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816941 |
Product Specific Information
This antibody detects endogenous levels of JunD only when phosphorylated at Ser259.
Target Information
JunD is a transcription factor encoded by the JunD gene. Its transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N-terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) pathway. Jun proteins form dimers with Fos, ATF, and CREB family transcription factors to create the AP-1 complex, which regulates genes involved in cellular growth, proliferation, differentiation, and apoptosis. JunD also plays an important role in metabolism through modulation of the IGF-1 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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