Thermo Fisher Scientific Phospho-CHK1 (Ser345) Polyclonal Antibody
CHK1 단백질의 Ser345 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에서 검증됨. DNA 손상 반응 연구 및 세포주기 조절 연구에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. 보존제 없음, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 141 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982437 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Chk1 when phosphorylated at other sites.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity under genotoxic stress.
When the G2 or S checkpoint is abrogated by CHK1 inhibition, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1.
CHK1 inhibitors can therefore potentiate the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, particularly in p53-deficient cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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