Thermo Fisher Scientific Phospho-EGFR (Tyr992) Polyclonal Antibody
EGFR Tyr992 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. 인간 및 랫트 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C 보관하며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA517835
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr992 of human EGF receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979059 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
EGFR is encoded by the EGFR gene located on chromosome 7 in humans and belongs to the HER/ERbB family of proteins, which includes ERbB2, ERbB3, and ERbB4.
Binding of ligands such as EGF and TGF-α to the extracellular domain leads to dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain. Overexpression is observed in various tumors including head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, and esophagus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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