Thermo Fisher Scientific Desmin Polyclonal Antibody
Desmin 단백질 검출용 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC(P), ICC/IF 실험에 적합합니다. 인간, 마우스, 랫 등 다양한 종에 반응하며, 고순도 Affinity chromatography로 정제된 액상 형태입니다. 근육세포 특이적 단백질 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DES (Accession P17661), corresponding to amino acid residues F428–L470 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899749 |
Product Specific Information
Antibody detects endogenous levels of total Desmin.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle). Its expression is stage- and tissue-specific, induced during terminal development of skeletal muscle cell differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk.
In smooth muscle, expression is more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-115113_Desmin_P17661-1_Rabbit.svg, PA5-115113_Desmin_P17661-1_Rabbit_PDP.jpeg)
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