Thermo Fisher Scientific WHIP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
CKKSGQSYSP SRVLITENDV KEGLQRSHIL YDRAGEEHYN CISALHKSMR GSDQNASLYW LARMLEGGED PLYVARRLVR FAS

Highest antigen sequence identity to the following orthologs:

• Mouse: 98%
• Rat: 98%

Target Information

Werner’s syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN).
The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein.
This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus.
It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human.
This protein likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis.
It also interacts with nucleoporins at nuclear pore complexes.
Two transcript variants encoding different isoforms have been isolated for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.