Thermo Fisher Scientific WHIP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
YQGCHFIGMP ECEVLLAQCV VYFARAPKSI EVYSAYNNVK ARLRNHQGPL PPVPLHLRNA PTRLMKDLGY G

Antigen sequence identity:

• Mouse: 97%
• Rat: 97%

Target Information

Werner’s syndrome is a rare autosomal recessive disorder characterized by accelerated aging caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. It contains a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. This protein shows sequence similarity to replication factor C family proteins and is conserved from E. coli to human. It likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins, binds to DNA polymerase delta, and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. Additionally, it interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.