Thermo Fisher Scientific CRX Monoclonal Antibody (4G11)
CRX 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며, PBS 기반 액상 형태로 제공됩니다. 시냅스 및 광수용체 관련 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G11 |
| Immunogen | CRX (NP_000545, 1–95 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCR
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin.
Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes.
The CRX gene is also expressed in pinealocytes of the pineal gland and may regulate pineal circadian activity by controlling melatonin synthesis gene expression.
Furthermore, CRX(-) mice exhibit disruption of circadian rhythms.
The human CRX gene maps to chromosome 19q13.3 within the cone-rod dystrophy-2 locus (CORD2).
Mutations in CRX are implicated in visual pathologies such as CORD, Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP).
All characterized CRX mutations produce disease in heterozygotes; missense mutations affect the homeobox domain, whereas frameshift mutations affect the OTX domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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