Thermo Fisher Scientific CRX Monoclonal Antibody (4G11)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCR

Target Information

The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin.
Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes.
The CRX gene is also expressed in pinealocytes of the pineal gland and may regulate pineal circadian activity by controlling melatonin synthesis gene expression.
Furthermore, CRX(-) mice exhibit disruption of circadian rhythms.
The human CRX gene maps to chromosome 19q13.3 within the cone-rod dystrophy-2 locus (CORD2).
Mutations in CRX are implicated in visual pathologies such as CORD, Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP).
All characterized CRX mutations produce disease in heterozygotes; missense mutations affect the homeobox domain, whereas frameshift mutations affect the OTX domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.