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Thermo Fisher Scientific DCTN2 Polyclonal Antibody
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Thermo Fisher Scientific DCTN2 Polyclonal Antibody

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Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal 항체로, Dynactin 2(p50 Dynamitin) 검출에 사용. WB, IHC, ICC/IF에 적합하며, 고순도 Affinity chromatography 정제. PBS/glycerol buffer에 보존, 연구용 전용 제품.

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Thermo Fisher Scientific PA5102604 DCTN2 Polyclonal Antibody 100 ul pk판매 단위 pk
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Thermo Fisher Scientific · Thermo Fisher Scientific DCTN2 Polyclonal Antibody

Applications

Western Blot (WB)

  • Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

  • Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

  • Tested Dilution: 1:100–1:500

Product Specifications

항목 내용
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen A synthesized peptide derived from human DCTN2 (Accession Q13561), corresponding to amino acid residues T351–K401
Conjugate Unconjugated
Form Liquid
Concentration 1 mg/mL
Purification Affinity chromatography
Storage Buffer PBS, pH 7.4, with 50% glycerol
Contains 0.02% sodium azide
Storage Conditions -20°C
Shipping Conditions Wet ice
RRID AB_2852006

Product Specific Information

Antibody detects endogenous levels of total p50 Dynamitin.


Target Information

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10–11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in diverse cellular functions, including:

  • ER-to-Golgi transport
  • Centripetal movement of lysosomes and endosomes
  • Spindle formation and chromosome movement
  • Nuclear positioning and axonogenesis

This subunit is present in 4–5 copies per dynactin molecule and contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and affix p150 in place.


For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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