Thermo Fisher Scientific DCTN2 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal 항체로, Dynactin 2(p50 Dynamitin) 검출에 사용. WB, IHC, ICC/IF에 적합하며, 고순도 Affinity chromatography 정제. PBS/glycerol buffer에 보존, 연구용 전용 제품.
- 카탈로그번호
- PA5102604
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DCTN2 (Accession Q13561), corresponding to amino acid residues T351–K401 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852006 |
Product Specific Information
Antibody detects endogenous levels of total p50 Dynamitin.
Target Information
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10–11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in diverse cellular functions, including:
- ER-to-Golgi transport
- Centripetal movement of lysosomes and endosomes
- Spindle formation and chromosome movement
- Nuclear positioning and axonogenesis
This subunit is present in 4–5 copies per dynactin molecule and contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and affix p150 in place.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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