Thermo Fisher Scientific CD22 Monoclonal Antibody (RFB-4), FITC

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: -
• Publications: View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent
• Publications: View 1 publication

Product Specifications

Additional Formats

• APC
• PE
• Request custom conjugation

Product Specific Information

FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

Target Information

CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130–140 kDa.
It is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell differentiation at approximately the same stage as CD19.
Membrane expression is limited to mature B cells (CD22+) and absent in plasma cells (CD22−), useful for phenotyping mature leukemias.
CD22 is strongly expressed in hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
It preferentially binds to alpha2,6-linked sialic acid and participates in regulation of B-cell receptor signaling through interactions with Src family tyrosine kinases and phosphatases.

Analyte Specific Reagent

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