Thermo Fisher Scientific IRF3 Polyclonal Antibody
IRF3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC에 적합하며, 액상 형태로 제공. 4°C 보관, 1년 안정성 보장. 바이러스 감염 관련 면역 반응 연구에 활용 가능.
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- A300426Ax (2개 옵션)
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 100 and 150 of human Interferon Regulatory Factor 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a critical role in the innate immune response against DNA and RNA viruses by regulating transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG).
IRF3 is inactive in the cytoplasm of uninfected cells and becomes activated through phosphorylation by IKBKE and TBK1 upon viral infection or toll-like receptor signaling.
This activation promotes dimerization, nuclear localization, and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), which drives IFN and ISG gene expression.
Mutations in IRF3 can lead to acute, infection-induced encephalopathy (herpes-specific 7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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