Thermo Fisher Scientific OX40L Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• This product is preservative-free.
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
• This antibody has specificity for Mouse OX40L.

Target Information

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane-bound, non-covalently linked homotrimeric protein. It is expressed on antigen-presenting cells such as dendritic cells and activated B cells, as well as on vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, which is expressed predominantly on CD4+ T cells and on certain activated CD8+ T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal required for productive interaction between antigen-presenting cells and their target T cells. It enhances cell proliferation and survival and increases expression of RANTES, IL-2, IL-3, and IFN-γ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.