Thermo Fisher Scientific TRAF3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
• This antibody has specificity for Human TRAF3.

Target Information

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Recent molecular cloning studies have led to identification of six TRAFs (TRAF1–TRAF6).
TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the TNF-alpha receptor-associated factors.
TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.