Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
인간 Synaptotagmin 1을 인식하는 Rabbit Polyclonal 항체로, WB에 최적화되어 있습니다. 보존제가 포함되지 않아 사용 전 NaN₃ 첨가를 권장합니다. 단백질 A 및 항원 친화 크로마토그래피로 정제되었으며, 신경전달 관련 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human SYT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788495 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human Synaptotagmin 1 (SYT1).
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS and functions as a Ca²⁺ sensor in exocytosis and neurotransmitter release.
It mediates Ca²⁺-dependent binding of SNAP25, essential for membrane fusion. Specific residues within the C2B binding domain regulate endocytic rate and synaptic vesicle size.
Synaptotagmin 1 binds acidic phospholipids requiring both an acidic head group and a diacyl backbone. It interacts Ca²⁺-dependently with receptors for activated protein kinase C and Ca²⁺-independently with neurexins, syntaxin, and AP2.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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