Thermo Fisher Scientific SQSTM1 Monoclonal Antibody (GT381)

Thermo Fisher Scientific SQSTM1 Monoclonal Antibody (GT381)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:3,000
• Immunocytochemistry (ICC/IF): 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: HepG2, A549, H1299, Huh-7 (untreated), Huh-7 (3 µM Thapsigargin treatment for 12 hr), Huh-7 (3 µM Thapsigargin treatment for 24 hr).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. The protein acts as a scaffolding/adaptor in concert with TNF receptor-associated factor 6 to mediate NF-κB activation in response to upstream signals.
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene.
Mutations in this gene result in sporadic and familial Paget disease of bone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.