Thermo Fisher Scientific TET1 Monoclonal Antibody (GT465)
TET1 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 고농축 액상 형태로 제공됩니다. 인간 TET1 중심 영역 재조합 단백질을 면역원으로 사용하였으며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific TET1 Monoclonal Antibody (GT465)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT465 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TET1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2787131 |
Product Specific Information
Keep as concentrated solution.
Positive Control: NT2D1, NT2D1 nuclear extract, DDDDK-human TET1-transfected 293T, M10.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TET1 is a dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA crucial for retrotransposon silencing and development. It catalyzes the conversion of 5mC to 5-hydroxymethylcytosine (hmC). The function of hmC remains unclear but may affect chromatin structure, recruit specific factors, or act as an intermediate in cytosine demethylation. hmC is present in ES cells and enriched in the brain, notably in Purkinje neurons, and may play a role in fetal development of the heart, lung, and brain.
Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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