Thermo Fisher Scientific CD34 Monoclonal Antibody (QBEND/10), FITC

Thermo Fisher Scientific CD34 Monoclonal Antibody (QBEND/10), FITC

Applications

• Immunohistochemistry (IHC)
  Tested dilution: Not specified
  View 21 publications
• Flow Cytometry (Flow)
  Tested dilution: Neat–1:10
  View publications

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• PE
• Request custom conjugation

Product Specific Information

• Does not react with bovine, dog, rat, or sheep.
• For FACS analysis: use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Mouse anti-Human CD34 antibody (clone QBEND/10) recognizes human CD34 antigen, also known as Hematopoietic progenitor cell antigen CD34.
• Quantity: 100 Tests / 1 mL.

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) found on various stem cell populations. It serves as a stem cell marker with reversible expression on human hematopoietic stem cells. CD34 may function as a surface receptor mediating endocytosis and regulating adhesion, differentiation, and proliferation of hematopoietic and progenitor cells. It likely plays a role in stem cell attachment to bone marrow extracellular matrix or stromal cells and may act as a scaffold for glycans enabling lectin interactions. The intracellular domain is phosphorylated by protein kinase C, suggesting involvement in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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