Thermo Fisher Scientific PTPRB Monoclonal Antibody (122.2)
PTPRB 단백질을 인식하는 mouse IgM 단일클론 항체로, rat 시료에 반응합니다. Western blot, ICC/IF, IP에 사용 가능하며, 1 mg/mL 액상 형태로 제공됩니다. 세포 성장 및 분화 관련 신호전달 연구에 적합한 연구용 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 122.2 |
| Immunogen | Embryonic rat brain proteoglycans |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion - Dialysis |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2173121 |
Product Specific Information
Predicted molecular weight: 224 kDa.
Target Information
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, which regulates various cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation.
This receptor-type PTP contains an extracellular domain with multiple fibronectin type III repeats, a single transmembrane segment, and an intracellular catalytic domain.
It interacts with neuronal receptors and adhesion molecules including contactin and tenascin C, and also with sodium channels, potentially regulating them via tyrosine phosphorylation.
These interactions suggest roles in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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