Thermo Fisher Scientific PKN2 Recombinant Rabbit Monoclonal Antibody (20A8)

Applications and Tested Dilutions

Product Specifications

Target Information

PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion, and transcription activation signaling processes. PKN2 phosphorylates CTTN in hyaluronan-induced astrocytes, decreasing CTTN ability to associate with filamentous actin. It phosphorylates HDAC5, impairing HDAC5 import. PKN2 acts as a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. It is required for G2/M phase progression and abscission during cytokinesis in an ECT2-dependent manner. Additionally, it stimulates FYN kinase activity necessary for skin cell-cell adhesion during keratinocyte differentiation, regulates epithelial bladder cell migration and invasion, inhibits Akt pro-survival kinase activity, and mediates Rho protein-induced transcriptional activation via c-fos serum response factor (SRF). PKN2 also phosphorylates HCV NS5B, leading to stimulation of HCV RNA replication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.