Thermo Fisher Scientific NF2 Recombinant Rabbit Monoclonal Antibody (JE31-02)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE31-02

Immunogen

Synthetic peptide within Human Merlin aa 546-595/595. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NF2,uniProtId:P35240-1,ncbiNodeId:9606,antigenRange:546-595,antigenLength:595,antigenImageFileName:MA5-50810_NF2_P35240-1_Rabbit.svg,antigenImageFileNamePDP:MA5-50810_NF2_P35240-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3094339

Product Specific Information

Positive control: Hela cell lysate, mouse brain tissue lysate, rat brain tissue lysate.

Predicted band size: 70 kDa

Subcellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus.

Target Information

NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.