Thermo Fisher Scientific NF2 Recombinant Rabbit Monoclonal Antibody (JE31-02)
NF2 단백질(Merlin)을 인식하는 재조합 토끼 단클론 항체로, Western blot에 적합. 인간, 생쥐, 랫트 반응성. HEK293 세포에서 발현된 IgG 형 항체로 Protein A로 정제됨. 세포막 및 세포골격 관련 Merlin 단백질 연구용.
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Applications
- Western Blot (WB): 1:500–1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE31-02 |
| Immunogen | Synthetic peptide within Human Merlin aa 546–595/595 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094339 |
Product Specific Information
- Positive control: Hela cell lysate, mouse brain tissue lysate, rat brain tissue lysate
- Predicted band size: 70 kDa
- Subcellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus
Target Information
NF2 encodes a protein, Merlin, that is similar to members of the ERM family, which link cytoskeletal components with membrane proteins. Merlin interacts with cell-surface proteins, cytoskeletal regulators, and ion transport proteins.
This gene is highly expressed during embryonic development and in adults is found in Schwann cells, meningeal cells, lens, and nerve.
Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors and ocular abnormalities.
Two predominant isoforms and several minor isoforms are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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