Thermo Fisher Scientific Phospho-4EBP1 (Thr37, Thr46) Polyclonal Antibody

Thermo Fisher Scientific Phospho-4EBP1 (Thr37, Thr46) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:10,000

Species Reactivity

• Human
• Mouse
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human 4E-BP1 (phospho Thr37/Thr46).
The exact sequence is proprietary.

Conjugate

• Unconjugated

Form

• Liquid

Concentration

• 0.12 mg/mL

Purification

• Antigen affinity chromatography

Storage Buffer

• PBS, pH 7, with 1% BSA, 20% glycerol

Contains

• 0.025% ProClin 300

Storage Conditions

• Store at 4°C short term
• For long term storage, store at -20°C, avoiding freeze/thaw cycles

Shipping Conditions

• Wet ice

RRID

• AB_2736348

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Product Specific Information

• Positive Control: Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, HeLa, 293T (starvation for 24 hr), 293T (starvation for 24 hr and 20% FBS treatment for 0.5 hr)
• Predicted Reactivity: Zebrafish (100%), Pig (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

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Target Information

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs.
Interaction of this protein with eIF4E inhibits complex assembly and represses translation.
This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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