Thermo Fisher Scientific Ephrin A5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Ephrin A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases crucial for migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. It binds promiscuously to Eph receptors on adjacent cells, leading to contact-dependent bidirectional signaling.
Forward signaling occurs downstream of the receptor, while reverse signaling occurs downstream of the ephrin ligand. Ephrin A5 induces compartmentalized signaling within caveolae-like membrane microdomains, requiring Fyn tyrosine kinase activity.
It activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With EPHA2, it may regulate lens fiber cell shape and interactions, contributing to lens transparency. Ephrin A5 also stimulates axon fasciculation and mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
As a cognate ligand for EPHA7, Ephrin A5 participates in brain development through modulation of cell-cell adhesion and repulsion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.