Thermo Fisher Scientific Ephrin A5 Polyclonal Antibody
Ephrin A5 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 실험에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Ephrin A5, amino acids 121–228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ephrin A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases crucial for migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. It binds promiscuously to Eph receptors on adjacent cells, leading to contact-dependent bidirectional signaling.
Forward signaling occurs downstream of the receptor, while reverse signaling occurs downstream of the ephrin ligand. Ephrin A5 induces compartmentalized signaling within caveolae-like membrane microdomains, requiring Fyn tyrosine kinase activity.
It activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With EPHA2, it may regulate lens fiber cell shape and interactions, contributing to lens transparency. Ephrin A5 also stimulates axon fasciculation and mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
As a cognate ligand for EPHA7, Ephrin A5 participates in brain development through modulation of cell-cell adhesion and repulsion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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