Thermo Fisher Scientific Phospho-HDAC4 (Ser632) Polyclonal Antibody
HDAC4 단백질의 Ser632 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간, 생쥐, 랫드 시료 반응. 고순도 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HDAC4 (Accession P56524), corresponding to amino acid residues around phosphorylated Ser632 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816402 |
Product Specific Information
This antibody detects endogenous levels of HDAC4 only when phosphorylated at Serine 632.
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation provides an epigenetic repression signal and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. HDAC4 acts via the formation of large multiprotein complexes and is involved in muscle maturation through interactions with myocyte enhancer factors (MEF2A, MEF2C, MEF2D). It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-104929_HDAC4_P56524-1_Rabbit.svg, PA5-104929_HDAC4_P56524-1_Rabbit_PDP.jpeg)
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