Thermo Fisher Scientific Human PDCD5 Synthetic Peptide
인간 PDCD5 단백질의 C-말단 21개 아미노산 서열로 구성된 합성 펩타이드. PDCD5 항체의 블로킹 펩타이드로 사용 가능. 세포자멸사 연구용으로 적합하며, 정제된 액상 형태로 제공. PBS 완충액에 보관하며 -20°C에서 안정적으로 저장.
- 카탈로그번호
- PEP0798
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 21 amino acids near the carboxy terminus of human PDCD5.
PEP-0798 can be used as a blocking peptide with polyclonal antibody PA5-20682.
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein that plays an early and universal role in apoptosis. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. It has a compact core structure with two mobile alpha-helices at the N-terminal and a flexible unstructured C-terminal region. Charged residues are crucial for apoptosis promotion and cell translocation. PDCD5 facilitates apoptosis and enhances TAJ/TROY-induced paraptosis-like cell death. It also interacts with Tip60 as a co-activator to promote apoptosis. Nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and may influence susceptibility to chronic myelogenous leukemia and lung cancer, suggesting a potential tumor suppressor role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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