Thermo Fisher Scientific Human PDCD5 Synthetic Peptide
인간 PDCD5 단백질의 N-말단 13개 아미노산 서열로 구성된 합성 펩타이드입니다. 항체 PA5-20684의 블로킹 펩타이드로 사용 가능합니다. 세포사멸 연구 및 PDCD5 관련 기능 연구에 적합합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0800
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the amino terminus of human PDCD5.
PEP-0800 can be used as a blocking peptide with polyclonal antibody PA5-20684.
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus.
It has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are crucial for apoptosis promotion and cell translocation.
PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death, and may play a dual role in the Tip60 pathway as a co-activator promoting apoptosis.
Nucleotide polymorphisms in the 5′-upstream region of PDCD5 affect promoter activity and susceptibility to chronic myelogenous leukemia, suggesting PDCD5 may act as a tumor suppressor gene influencing lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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