Thermo Fisher Scientific Human ZFYVE26 Synthetic Peptide

Thermo Fisher Scientific Human ZFYVE26 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human SPG15.
PEP-0801 can be used as a blocking peptide with polyclonal antibody PA5-20685.

Target Information

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.
Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia characterized by mental retardation and muscle stiffness at onset, followed by slowly progressive paraparesis and cognitive deterioration.
SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.

SPG15 encodes a protein containing a FYVE zinc finger binding domain, which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues and rat embryos, suggesting a possible role during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, indicating a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.