Thermo Fisher Scientific Human NPAS3 Synthetic Peptide
인간 NPAS3 단백질의 중심부 28개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 폴리클로날 항체 PA5-20365의 블로킹 펩타이드로 사용 가능합니다. 고순도 액상 형태로 제공되며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Human NPAS3 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 28 amino acids near the center of human NPAS3.
PEP-0485 can be used as a blocking peptide with polyclonal antibody PA5-20365.
Target Information
Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor. It is broadly expressed in the developing neuroepithelium and has been found to be disrupted by genetic translocation in a family affected with schizophrenia.
NPAS3 regulates FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1, influencing neurogenesis from this region.
NPAS3-deficient mice show growth retardation and brain defects such as reduced anterior hippocampus size, corpus callosum hypoplasia, enlarged ventricles, and behavioral abnormalities. They also exhibit disruptions in neurosignaling pathways involving glutamate, dopamine, and serotonin.
These findings demonstrate the essential role of NPAS3 in structural and functional brain development. At least three isoforms of NPAS3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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