Thermo Fisher Scientific Human NPAS3 Synthetic Peptide

Thermo Fisher Scientific Human NPAS3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 28 amino acids near the center of human NPAS3.
PEP-0485 can be used as a blocking peptide with polyclonal antibody PA5-20365.

Target Information

Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor. It is broadly expressed in the developing neuroepithelium and has been found to be disrupted by genetic translocation in a family affected with schizophrenia.
NPAS3 regulates FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1, influencing neurogenesis from this region.
NPAS3-deficient mice show growth retardation and brain defects such as reduced anterior hippocampus size, corpus callosum hypoplasia, enlarged ventricles, and behavioral abnormalities. They also exhibit disruptions in neurosignaling pathways involving glutamate, dopamine, and serotonin.
These findings demonstrate the essential role of NPAS3 in structural and functional brain development. At least three isoforms of NPAS3 are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.