Thermo Fisher Scientific Human NPAS3 Synthetic Peptide
인간 NPAS3 단백질의 N-말단 28개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20364의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0484
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 28 amino acids near the amino terminus of human NPAS3.
PEP-0484 can be used as a blocking peptide with polyclonal antibody PA5-20364.
Target Information
Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor that is broadly expressed in the developing neuroepithelium. It has been associated with genetic translocation in a family affected by schizophrenia. NPAS3 regulates FGF signaling in the dentate gyrus by controlling FGF receptor subtype 1 expression, influencing neurogenesis.
NPAS3-deficient mice show growth retardation, brain structural defects (including reduced anterior hippocampus size, corpus callosum hypoplasia, and enlarged ventricles), and behavioral abnormalities. They also exhibit disruptions in neurosignaling pathways involving glutamate, dopamine, and serotonin, highlighting NPAS3's essential role in brain development.
At least three isoforms of NPAS3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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